The change in administration brought significant changes to the research ecosystem in 2025. From funding to administration to oversight to workforce, no aspect of the biomedical research enterprise has been unaffected, leaving institutions struggling to adapt quickly to unanticipated changes. This opening address will provide attendees with an overview of how major changes in NIH funding, research grant stability, and federal agency personnel have shifted the foundations of the federal partnership for research. The session will incorporate your questions, address how fiscal and competitive pressures may be impacting research compliance activities, and provide a national perspective from the Association of American Medical Colleges on how the community is responding and what may lie ahead.