This panel examines how culture shapes research integrity across international and cross-cultural collaborations, with a focus on implications for education, prevention, and investigations of research misconduct. Panelists will present empirical findings on cultural differences in strategies for ethical decision-making and views of research values and conduct. Differing cultural perspectives shape interpretations of appropriate research conduct, perceptions of rule violations, and views of their consequences. Panelists will invite audience questions and discuss best practices for cross-cultural research education, misconduct prevention, and fair, culturally informed investigations.